Have you taken Folate and it caused anxiety, insomnia, or other signs of agitation? You could be undermethylated.
If you've been tested for MTHFR and found to have a single nuclear polymorphism (SNP), often the first treatment is adding folate. But it isn't just about one enzyme in the methylation pathway; it's a tug of war between a bunch of enzymes on either side that can make you more undermethylated or overmethylated.
Methylation is also more than that one little biochemical pathway, sometimes called the one carbon cycle. Methyl groups can also modify genes and modify the expression of genes, either inhibiting or increasing expression.
Instead of looking at one biochemical pathway, or just a handful of enzymes, I ask you a lot of questions about your signs, symptoms, tendencies, current pharmaceuticals, reactions to drugs and more. Then I send you to get some labs drawn at a standard lab that will give me answers about which nutrients would be most helpful and which doses would be best.
Just having an MTHFR mutation/SNP is not enough information, and neither is homocysteine. It's a piece of the puzzle, but not the whole answer. If you've gone down that road and not seen results, come in for an assessment and testing.
Spotted Jewelweed (Impatiens biflora) is an invaluable tool when out in the woods hiking. The saponins found in the stem or leaves can emulsify and diminish the damage caused by poison ivy. It's also great for bug bites, rashes from stinging nettles, burns, cuts, acne, eczema, fungal infections, or any other skin irritation.